The gaseous substance we call medical ozone is actually a mixture of primarily pure oxygen (95.0 to 99.5%) and a small amount of ozone (0.5-5.0%). It is well accepted that many diseases, whether acute or chronic, are characterized by free radical oxidant stress, causing patients to suffer from poor energy production and fatigue. Consequently, all patients with chronic oxidant stress are observed to improve when oxidant therapy is administered.
Medical Ozone and Free Radical Production
Sources of free radicals are viruses, bacteria, parasites, normal respiration and metabolism, exposure to pollutants, exposure to the sun, x-rays, injury, and stress to name a few. Naturally occurring free radicals are nitric oxide (NO), hydroxyl ions (OH-), and the oxygen anion (O-), also known as singlet oxygen, the latter resulting from the breakdown of the ozone molecule.
When medical ozone enters the water fraction of plasma, its first order of preference is to attack lipids, especially polyunsaturated fatty acids (PUFA’s). Second it is neutralized by antioxidants such as vitamin E, C, glutathione, bilirubin, cysteine rich proteins and carbohydrates. PUFA’s are found in cell walls and membranes, lipoproteins, triglycerides, and chylomicrons. As a result of this ozone-lipid reaction, ozonides, peroxides, aldehydes, and other free radicals are formed.
Medical ozone, not a free radical itself, does not cause significant free radical damage when introduced into the body because:
Effects of Introducing Medical Ozone into Biological Systems
When we take these three statements together, we find that ozone therapy offers a very effective solution to health problems. When correct doses of medical ozone are given, it stimulates free radical buffering systems, it can kill bacteria (bactericidal), viruses(virostatic), fungus(fungicidal), and parasites(parasiticidal), and it stimulates the production of all the cytokine systems of the body, specifically interleukin -2 ( secreted by T helper cells), interferon, and tumour necrosis factor, and stimulates the production of white blood cells. Thus, it eliminates microbes by direct kill and indirectly as in the vaccine example.
In addition to being valuable in antimicrobial therapy, medical ozone breaks down petrochemicals, increases the flexibility and elasticity of red blood cells, and oxidizes arterial plaque. Very importantly, it increases the red blood cell enzyme 2, 3 DPG, which catalyzes the release of oxygen from red blood cells into tissues, and very importantly, accelerates the Krebs or citric acid cycle. We will discuss this last and very important benefit of medical ozone below.